July 15th, 2019
Based on a proposal ranked 'excellent', Frame Therapeutics B.V. obtained an SME instruments phase I grant to strengthen their business strategy towards market entry with personalized and off-the-shelf cancer vaccines for all cancer patients. Frame’s proposal scored in the top 5% out of almost 3,000 proposals submitted in this SME instruments funding round.
The SME instruments funding is available for 'top-class innovators, entrepreneurs, small companies and scientists and provides support with funding opportunities and acceleration services.' Frame Therapeutics will use this support to further grow from an early startup (founded December 2018) to a clinical stage company that develops vaccines against the individual tumors of cancer patients. Frame vaccines are based on the DNA composition of the tumor, and in particular on FRAMES (neoantigens that result from frameshift mutations in genes in the tumor). With the SME grant (€50.000) the company can design strategies to strengthen its IP position, develop preclinical as well as clinical research plans, and define a portfolio of vaccine products for several major cancer types. The SME support brings Frame into a position where subsequent major investments allow execution of these plans.
April 29th, 2019
A Scientific Report by Koster and Plasterk, published on April 29th 2019, describes frame shifts in tumor driver genes. The frame shift mutations were found in public databases of over 10,000 different tumors from different cancer patients. These patients have nothing in common, except that they all have one or another form of cancer; that is the reason that they often have frame shift mutations in a small set of so-called ‘tumor driver’ genes. As a result they have often neoantigens (new peptides encoded) that are shared with many other cancer patients. In some tumor types ‘Frames’ (defined as neoantigen peptides encoded as result of a frame shift mutation) are found within one or only a few genes. This opens the possibility to design and manufacture anti-cancer vaccines in advance, to be used off the shelf without time lost for patients whose tumor DNA has been sequenced.
March 21, 2019
On the 21st of March, Matrix VII has been officially opened -with great festivities- by Amsterdam alderman of Economic Affairs Udo Kock. The building, designed by Ector Hoogstad architects, offers laboratory facilities for high-tech companies. Matrix VII is situated in Amsterdam Science Park. Today Amsterdam Science Park is the center par excellence when science and technology are involved.
February 1, 2019
On the 1st of February Frame was launched in the brand-new Matrix VII building with a bang! The building of Matrix VII is built to become the epicentre of science and biotech.
December 27, 2018
On the 27th of December 2018, Frame was officially founded by Ronald Plasterk, Dinko Valerio and Bob Lowenberg. The beginning of a new endeavour!
Ronald Plasterk, Founder and CEO of Frame filed the first of a series of patents early 2018. This was the first step to the start of Frame.